Manchester City's latest defeat allowed Liverpool to move eight points clear at the top of the table, with the Reds now firmly installed as the favourites in the Premier League betting odds.
Arsenal got back on track and there was also a victory for Chelsea, but the top story is certainly City losing again despite their manager Pep Guardiola having signed a new contract extension.
Man City drop points again
It is five defeats in a row in all competitions for City now, with three successive league losses allowing Liverpool to take a firm grip of the title race. Hosting Tottenham in Saturday's late game, City paraded Rodri's Ballon d'Or ahead of kick-off but they still badly missed their key midfielder as James Maddison ran riot in a stunning 4-0 victory for Spurs.
City are still sat in second spot but with a massive gap to make up on Liverpool - who they play next in the league - their chances of a fifth straight Premier League title are slipping away. From 23/10 prior to the international break, City's title odds have pushed back all the way to 7/2.
Liverpool only recently moved to the top of the betting but Arne Slot's highly impressive side are now the 4/5 favourites in the Premier League outright winner market. The Reds did not have life easy at Southampton on Sunday and they were bailed out by a brace from star man Mo Salah.
Like City, Arsenal have been wobbling badly of late but the Gunners got back on track with a comfortable 3-0 home win against Nottingham Forest. Mikel Arteta's men are third in the table but are around 3/1 in the title race betting odds, ahead of City who are now third-favourites.
Title talk is building at Chelsea, who may emerge as Liverpool's main competition. A 2-1 victory at Enzo Maresca's old side Leicester City means the Blues have taken eight points from their last four games since losing at Liverpool, their only defeat since the opening game. Chelsea are 22/1 in the Premier League title race betting odds but they cannot be written off.
Man City are best priced to win the PL title at Coral, with odds of 7/2 as of November 25.
Brighton dreaming of Champions League
Only outside the top four on goal difference, Brighton won 2-1 at Bournemouth on Saturday to record successive victories in the Premier League. The Seagulls had previously gone on a three-game winless run but they have got back on their feet and are European contenders.
Brighton are still out at 6/1 in the Premier League top-four finish betting odds, while Chelsea remain favoured at 4/6 behind Liverpool, City and Arsenal in that particular betting market.
Tottenham blew City away to lay down a marker but they have three points to make up on the teams above them in the race for Champions League places. Spurs are 5/2 in the top-four finish odds while Newcastle, who are at home to West Ham on Monday night, can be backed at 4/1.
Brighton are best priced to finish top four in PL at BetMGM, with odds of 6/1 as of November 25.
Wolves out of drop zone after key win
Another vital victory for Wolves means that they have climbed out of the relegation zone. They won 4-1 away to Fulham to move narrowly above the dreaded dotted line in the league table.
Gary O'Neil's team are now 5/2 in the Premier League relegation odds while Leicester sacking Cooper does not seem to have done their chances any favours in the eyes of the bookies. The Foxes are 4/6 to be relegated while Crystal Palace, now in the drop zone, are priced at 4/1.
Ipswich held Manchester United to a 1-1 draw in Ruben Amorim's first game in charge. The Tractor Boys are level with Wolves on points but priced up at 4/6 to suffer relegation. Bottom side Southampton are seen as 1/7 certainties to be relegated back to the second tier.
Wolves are best priced to be relegated from PL at LiveScore Bet, with odds of 5/2 as of November 25.
Salah chasing down Haaland in Golden Boot race
Erling Haaland is still a clear favourite in the Premier League Golden Boot betting odds, but the in-form Liverpool star Mohamed Salah continues to close the Manchester City striker down.
Haaland drew another blank at the weekend while Salah struck twice to down Southampton and move within two goals of the front-runner, with Salah on 10 and Haaland still stuck on 12. Salah's Golden Boot winner odds are now at 9/2 after he maintained his stunning run of form at Southampton while Haaland's price has drifted out from 1/5 in recent weeks to 1/3.
Nicolas Jackson is developing fast with the Chelsea striker moving to seven league goals for the season this weekend. The striker is now at 20/1 to win the Golden Boot this season.
Mohamed Salah is best priced to win PL top goalscorer at Unibet, with odds of 9/2 as of November 25.
Steven is an experienced iGaming content writer who has been working in the industry since 2018. He is passionate about sports betting and enjoys writing about all aspects of the industry, including bookmaker reviews, betting tips and strategies, and news and analysis.